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Bruce A McClane Selected Research

Clostridium perfringens theta-toxin

1/2014Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease.
1/2011Epsilon-toxin production by Clostridium perfringens type D strain CN3718 is dependent upon the agr operon but not the VirS/VirR two-component regulatory system.
1/2008Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.
9/2006Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model.

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Bruce A McClane Research Topics

Disease

35Foodborne Diseases
01/2021 - 08/2002
20Diarrhea
01/2021 - 04/2004
13Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
10/2021 - 01/2005
8Infections
01/2019 - 10/2008
8Enteritis
11/2014 - 09/2006
7Neoplasms (Cancer)
12/2016 - 04/2007
4Enterotoxemia
01/2019 - 01/2011
3Intestinal Diseases (Diseases, Intestinal)
11/2014 - 01/2010
2Necrosis
12/2019 - 08/2008
2Gas Gangrene (Gangrene, Gas)
01/2018 - 08/2006
2Edema (Dropsy)
10/2016 - 08/2008
1Colic (Abdominal Cramps)
01/2021
1Hyperkalemia
01/2019
1Animal Diseases
01/2018
1Enterocolitis
09/2008
1Hemorrhage
08/2008
1Clostridium Infections
05/2008
1Necrotizing Enterocolitis
12/2007
1Ovarian Epithelial Carcinoma
04/2007

Drug/Important Bio-Agent (IBA)

25Enterotoxins (Enterotoxin)IBA
01/2021 - 08/2002
18Anti-Bacterial Agents (Antibiotics)IBA
12/2019 - 05/2005
13Clostridium enterotoxinIBA
01/2019 - 04/2007
8Proteins (Proteins, Gene)FDA Link
12/2019 - 04/2004
4Pharmaceutical PreparationsIBA
01/2019 - 01/2013
4ClaudinsIBA
10/2016 - 01/2010
4Clostridium perfringens theta-toxinIBA
01/2014 - 09/2006
3Virulence Factors (Pathogenicity Factors)IBA
01/2021 - 01/2011
3AcidsIBA
01/2016 - 05/2008
2N-formyl-13-dihydrocarminomycin (NFD)IBA
10/2021 - 12/2018
2Neuraminidase (Sialidase)IBA
10/2021 - 11/2014
2TrypsinIBA
06/2015 - 10/2008
2Claudin-4IBA
01/2008 - 04/2007
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
12/2019
1Threonine (L-Threonine)FDA Link
12/2019
1Serine (L-Serine)FDA Link
12/2019
1Phosphotransferases (Kinase)IBA
12/2019
1Quinacrine (Mepacrine)IBA
01/2019
1AcridinesIBA
01/2019
1Therapeutic UsesIBA
01/2019
1Indicators and Reagents (Reagents)IBA
10/2016
1Ion Channels (Ion Channel)IBA
10/2016
1Clostridium perfringens epsilon-toxinIBA
10/2016
1DNA (Deoxyribonucleic Acid)IBA
01/2016
1EnzymesIBA
03/2014
1Peptide Hydrolases (Proteases)FDA Link
01/2014
1Type C PhospholipasesIBA
01/2014
1Enterotoxin ReceptorsIBA
01/2012
1Biological ProductsIBA
01/2012
1Claudin-3IBA
01/2012
1aerolysinIBA
10/2011
1ThiamphenicolIBA
01/2011
1Peptides (Polypeptides)IBA
01/2011
1Tetracycline (Achromycin)FDA LinkGeneric
01/2011
1Chloramphenicol (Chloromycetin)FDA Link
01/2011
1NitritesIBA
07/2009
1Trypsin InhibitorsIBA
10/2008
1Calmodulin (Calcium-Dependent Activator Protein)IBA
01/2005
1CalpainIBA
01/2005
1BuffersIBA
01/2005
1OccludinIBA
04/2004

Therapy/Procedure

5Therapeutics
01/2019 - 01/2013
1Aftercare (After-Treatment)
06/2015
1Transjugular Intrahepatic Portasystemic Shunt
08/2008
1Drug Therapy (Chemotherapy)
01/2008